FAP is caused by a mutation in the adenomatous polyposis coli (APC) gene coding for APC protein, which acts as a tumor suppressor and keeps cells from growing too fast or in an uncontrolled way. It is characterized by polyps developing as early as the teens.1-3
80% OF CRC PATIENTS 80% OF CRC PATIENTS have an APC mutation.
Erythromycin treatment shown to reduce both the amount and size of polyps
Response to ZKN-013 shown in tumor grafts ex-vivo from patients with FAP derived CRC